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| | 2023, vol. 74, br. 6, str. 41-46 | Korelacija koncentracije C-reaktivnog proteina i prokalcitonina sa brojem leukocita u akutnoj infekciji i sepsi The correlation of concentration of C-reactive protein and procalcitonin with white blood cells count in acute infection and sepsis Đorđević Jelenaa, Pavlović Sofijaa, Makulović Stefana, Todorović Petara, Osmanović Eminaa, Terzić Kristinaa, Mihaljević Olgicab aUniverzitet u Kragujevcu, Fakultet medicinskih nauka, Srbija bUniverzitet u Kragujevcu, Fakultet medicinskih nauka, Katedra za patološku fiziologiju, Srbija e-adresa:jeladj997@gmail.com Ključne reči: C-reaktivni protein; infekcija; prokalcitonin; leukociti; sepsa Keywords: C-reactive protein; infection; leukocytes; procalcitonin; sepsis Sažetak Uvod: Infekcija je specifičan odgovor organizma na prodiranje i razmnožavanje mikroorganizma u biološki sistem. Za razliku od infekcije, sepsu karakteriše sistemski inflamatorni odgovor organizma. Najčešće korišćeni biomarkeri za postavljanje dijagnoze infekcije i sepse su C-reaktivni protein (CRP) i prokalcitonin (PCT). Cilj: Osnovni cilj istraživanja bio je da se ispita korelacija koncentracije CRP i PCT sa brojem leukocita kod pacijenata sa akutnom infekcijom i sepsom. Materijal i metode: Ovom retrospektivnom studijom je obuhvaćeno 69 pacijenata kod kojih je, radi utvrđivanja prisustva infekcije tokom hospitalizacije, urađena analiza krvi u Centralnoj laboratoriji Univerzitetskog kliničkog centra u Kragujevcu. Pacijenti su podeljeni u dve grupe: pacijenti sa lokalnom bakterijskom infekcijom različite lokalizacije i pacijenti sa sepsom. U grupi pacijenata sa lokalnom infekcijom izdvojene su četiri podgrupe: pacijenti sa infekcijama respiratornog trakta, urinarnog trakta, gastrointestinalnog i hepatobilijarnog trakta, i grupa pacijenata sa infekcijama kože. Kontrolna grupa bila je sastavljena od 40 zdravih ispitanika. U studiji su analizirani podaci o parametrima zapaljenja: broj leukocita, neutrofila i limfocita, CRP i PCT. Rezultati: Analiza pomenutih parametara ukazala je da pacijenti sa infekcijom/sepsom imaju statistički značajno veće vrednosti ukupnog broja leukocita (p<0,001), neutrofila (p<0,001), limfocita (p=0,007), CRP (p<0,001) i PCT (p<0,001) u odnosu na kontrolne ispitanike. Utvrđena je statistički značajna razlika u koncentraciji PCT između ispitivanih grupa pacijenata (p=0,029), tako da su najviše vrednosti zabeležene kod pacijenata sa sepsom. Kod pacijenata sa sepsom postoji značajna pozitivna korelacija koncentracije CRP i ukupnog broja leukocita (r=0,538, p=0,008). Zaključak: Kod pacijenata sa lokalnom infekcijom i sepsom postoji značajan porast koncentracije C-reaktivnog protein i prokalcitonina. Koncentracija C-reaktivnog protein pozitivno korelira sa stepenom leukocitoze u ispitivanoj populaciji. Abstract Introduction: Infection is a specific response to an active or passive pathogen penetration and/or its reproduction in the biological system. Unlike the infection, sepsis is characterized by a systemic inflammation response of the host. The most commonly used biomarkers for the diagnosis of infections and sepsis are C-reactive protein (CRP) and procalcitonin (PCT). Aim: The aim of the study was to examine the correlation of CRP and PCT with white blood cells (WBC) count in patients with acute infection and sepsis. Material and methods: This retrospective study included 69 patients who underwent a blood test at the Central Laboratory of the University Clinical Center of Kragujevac to determine the presence of infection/sepsis during hospitalization. Patients were divided into two groups: patients with local bacterial infections of different localization and patients with sepsis. In the group of patients with local infection, four subgroups were distinguished: patients with respiratory tract infections, urinary tract infections, gastrointestinal and hepatobiliary infections, and skin infections. The control group comprised 40 healthy subjects. The study analyzed data about WBC count, neutrophil and lymphocytes count as well as the concentration of CRP and PCT. Results: The analysis of mentioned parameters indicated that patients with infection/sepsis had significantly higher values of WBC (p<0.001), neutrophils (p<0.001), lymphocytes (p=0.007), CRP (p<0.001) and PCT (p<0.001) concerning control subjects. There was a statistically significant difference in PCT between the examined groups of patients (p=0.029), so the highest values have been recorded in septic patients. In patients with sepsis, there was a significant positive correlation between the concentration of CRP and WBC counts (r=0.538, p=0.008). 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